Veranstaltungen

29. Oktober 2019, 17:30 bis 00:00

Hand-held DNA-sequencing and biosensing with nanopores

Andere

Vortrag von Prof. Dr. Stefan Howorka, University College London, Department of Chemistry

Portable DNA sequencing and biosensing can advance research, bedside-diagnostics, and

homeland security. I describe how label-free sensing is achieved with atom-scale designed

membrane nanopores. In this strategy, nanopores act as electronic sensors that detect when

individual molecules pass the pores’ nanoscale hole. The temporary blockages cause changes

in ionic pore current. The approach has helped pioneer portable DNA sequencing with protein

pores(1) to discriminate individual bases. More recently, synthetic pores have been built by

folding DNA strands into defined channels(2). The DNA nanopores are relevant as they overcome the narrow size range of protein pores and thereby accommodate folded protein analytes. The DNA nanostructures are also easier to rationally design than proteins(3) and thereby

enable new applications, also in synthetic biology(4).

(1) Nature 2014 516 250;

(2) Nat. Nanotechnol. 2016 11 152;

(3) Nat. Nanotechnol. 2017 12 619;

(4) Science 2016 352 890; Nat. Chem. 2017 9 611

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Kalendereintrag

Veranstaltungsort

Lise-Meitner-Hörsaal, Fakultät für Physik, Universität Wien
1090 Wien
Strudlhofgasse 4/Boltzmanngasse 5, 1. Stock

 

Veranstalter

Chemisch-Physikalische Gesellschaft
Gerhard Schütz
schuetz@iap.tuwien.ac.at

 

Info-Link

https://www.cpg.univie.ac.at/

 

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