Veranstaltungen
29. Oktober 2019, 17:30 bis 00:00
Hand-held DNA-sequencing and biosensing with nanopores
Andere
Portable DNA sequencing and biosensing can advance research, bedside-diagnostics, and
homeland security. I describe how label-free sensing is achieved with atom-scale designed
membrane nanopores. In this strategy, nanopores act as electronic sensors that detect when
individual molecules pass the pores’ nanoscale hole. The temporary blockages cause changes
in ionic pore current. The approach has helped pioneer portable DNA sequencing with protein
pores(1) to discriminate individual bases. More recently, synthetic pores have been built by
folding DNA strands into defined channels(2). The DNA nanopores are relevant as they overcome the narrow size range of protein pores and thereby accommodate folded protein analytes. The DNA nanostructures are also easier to rationally design than proteins(3) and thereby
enable new applications, also in synthetic biology(4).
(1) Nature 2014 516 250;
(2) Nat. Nanotechnol. 2016 11 152;
(3) Nat. Nanotechnol. 2017 12 619;
(4) Science 2016 352 890; Nat. Chem. 2017 9 611
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Veranstaltung Details
- Veranstaltungsort
-
Lise-Meitner-Hörsaal, Fakultät für Physik, Universität Wien
1090 Wien
Strudlhofgasse 4/Boltzmanngasse 5, 1. Stock - Veranstalter
-
Chemisch-Physikalische Gesellschaft
Gerhard Schütz
schuetz@iap.tuwien.ac.at - Info-Link
- https://www.cpg.univie.ac.at/
- Öffentlich
- Ja
- Kostenpflichtig
- Nein
- Anmeldung erforderlich
- Nein