Articles
- | CD3 aptamers promote expansion and persistence of tumor-reactive T cells for adoptive T cell therapy in cancer at reposiTUm , opens an external URL in a new windowPuravankara Menon, A., Villanueva, H., Meraviglia-Crivelli, D. H., van Santen, H. M., Hellmeier, J., Zheleva, A., Nonateli, F., Peters, T., Wachsmann, T. L. A., Hernandez-Rueda, M., Huppa, J. B., Schütz, G., Sevcsik, E., Moreno, B., & Pastor, F. (2024). CD3 aptamers promote expansion and persistence of tumor-reactive T cells for adoptive T cell therapy in cancer. MOLECULAR THERAPY NUCLEIC ACIDS, 35(2), Article 102198. https://doi.org/10.1016/j.omtn.2024.102198
- | Exploring FGFR3 mutations in the male germline: implications for clonal germline expansions and paternal age-related dysplasias at reposiTUm , opens an external URL in a new windowMoura, S., Hartl, I., Brumovska, V., Calabrese, P. P., Yasari, A., Striedner, Y., Bishara, M., Mair, T., Ebner, T., Schütz, G., Sevcsik, E., & Tiemann-Boege, I. (2024). Exploring FGFR3 mutations in the male germline: implications for clonal germline expansions and paternal age-related dysplasias. Genome Biology and Evolution, 16(2), Article evae015. https://doi.org/10.1093/gbe/evae015
- | Measurement of FGFR3 signaling at the cell membrane via total internal reflection fluorescence microscopy to compare the activation of FGFR3 mutants at reposiTUm , opens an external URL in a new windowHartl, I., Brumovska, V., Striedner, Y., Yasari, A., Schütz, G., Sevcsik, E., & Tiemann-Boege, I. (2023). Measurement of FGFR3 signaling at the cell membrane via total internal reflection fluorescence microscopy to compare the activation of FGFR3 mutants. Journal of Biological Chemistry, 299(2), Article 102832. https://doi.org/10.1016/j.jbc.2022.102832
- | Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion at reposiTUm , opens an external URL in a new windowPlatzer, R., Hellmeier, J., Göhring, J., Perez, I. D., Schatzlmaier, P., Bodner, C., Focke-Tejkl, M., Schütz, G. J., Sevcsik, E., Stockinger, H., Brameshuber, M., & Huppa, J. B. (2023). Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion. EMBO Reports, Article e57842. https://doi.org/10.15252/embr.202357842
- | DNA origami demonstrate the unique stimulatory power of single pMHCs as T cell antigens at reposiTUm , opens an external URL in a new windowHellmeier, J., Platzer, R., Eklund, A. S., Schlichthaerle, T., Karner, A., Motsch, V., Schneider, M. C., Kurz, E., Bamieh, V., Brameshuber, M., Preiner, J., Jungmann, R., Stockinger, H., Schütz, G. J., Huppa, J. B., & Sevcsik, E. (2021). DNA origami demonstrate the unique stimulatory power of single pMHCs as T cell antigens. Proceedings of the National Academy of Sciences, 118(4). https://doi.org/10.1073/pnas.2016857118
- | Strategies for the Site-Specific Decoration of DNA Origami Nanostructures with Functionally Intact Proteins at reposiTUm , opens an external URL in a new windowHellmeier, J., Platzer, R., Mühlgrabner, V., Schneider, M. C., Kurz, E., Schütz, G. J., Huppa, J. B., & Sevcsik, E. (2021). Strategies for the Site-Specific Decoration of DNA Origami Nanostructures with Functionally Intact Proteins. ACS Nano, 15(9), 15057–15068. https://doi.org/10.1021/acsnano.1c05411
- | Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes at reposiTUm , opens an external URL in a new windowSchromm, A. B., Paulowski, L., Kaconis, Y., Kopp, F., Koistinen, M., Donoghue, A., Keese, S., Nehls, C., Wernecke, J., Garidel, P., Sevcsik, E., Lohner, K., Sanchez-Gomez, S., Martinez-de-Tejada, G., Brandenburg, K., Brameshuber, M., Schütz, G. J., Andrä, J., & Gutsmann, T. (2021). Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes. Proceedings of the National Academy of Sciences, 118(27). https://doi.org/10.1073/pnas.2101721118
- | Monte Carlo simulations of protein micropatterning in biomembranes: effects of immobile nanofeatures with reduced diffusivity at reposiTUm , opens an external URL in a new windowArnold, A. M., Reismann, A. W. A. F., Sevcsik, E., & Schütz, G. J. (2020). Monte Carlo simulations of protein micropatterning in biomembranes: effects of immobile nanofeatures with reduced diffusivity. Journal of Physics D: Applied Physics, 53(43), 435401. https://doi.org/10.1088/1361-6463/aba297
- | Unscrambling fluorophore blinking for comprehensive cluster detection via photoactivated localization microscopy at reposiTUm , opens an external URL in a new windowPlatzer, R., Rossboth, B. K., Schneider, M. C., Sevcsik, E., Baumgart, F., Stockinger, H., Schütz, G. J., Huppa, J. B., & Brameshuber, M. (2020). Unscrambling fluorophore blinking for comprehensive cluster detection via photoactivated localization microscopy. Nature Communications, 11(4993). https://doi.org/10.1038/s41467-020-18726-9
- | Homo- and Heteroassociations Drive Activation of ErbB3 at reposiTUm , opens an external URL in a new windowVaradi, T. E., Schneider, M., Sevcsik, E., Kiesenhofer, D., Baumgart, F., Batta, G., Kovács, T., Platzer, R., Huppa, J. B., Szöllősi, J., Schütz, G., Brameshuber, M., & Nagy, P. (2019). Homo- and Heteroassociations Drive Activation of ErbB3. Biophysical Journal, 117(10), 1935–1947. https://doi.org/10.1016/j.bpj.2019.10.001
- | A Fast and Simple Contact Printing Approach to Generate 2D Protein Nanopatterns at reposiTUm , opens an external URL in a new windowLindner, M., Tresztenyak, A., Fülöp, G., Jahr, W., Prinz, A., Prinz, I., Danzl, J. G., Schütz, G. J., & Sevcsik, E. (2019). A Fast and Simple Contact Printing Approach to Generate 2D Protein Nanopatterns. Frontiers in Chemistry, 6. https://doi.org/10.3389/fchem.2018.00655
- | A micropatterning platform for quantifying interaction kinetics between the T cell receptor and an intracellular binding protein at reposiTUm , opens an external URL in a new windowMotsch, V., Brameshuber, M., Baumgart, F., Schütz, G. J., & Sevcsik, E. (2019). A micropatterning platform for quantifying interaction kinetics between the T cell receptor and an intracellular binding protein. Scientific Reports, 9(3288). https://doi.org/10.1038/s41598-019-39865-0
- | Monomeric TCRs Drive T Cell Antigen Recognition at reposiTUm , opens an external URL in a new windowBrameshuber, M., Kellner, F., Rossboth, B., Ta, H., Alge, K., Sevcsik, E., Göhring, J., Axmann, M., Baumgart, F., Gascoigne, N. R. J., Darvis, S. J., Stockinger, H., Schütz, G., & Huppa, J. B. (2018). Monomeric TCRs Drive T Cell Antigen Recognition. Nature Immunology, 19(5), 487–496. https://doi.org/10.1038/s41590-018-0092-4
- | Determination of the Membrane Environment of CD59 in Living Cells at reposiTUm , opens an external URL in a new windowFülöp, G., Brameshuber, M., Arnold, A., Schütz, G., & Sevcsik, E. (2018). Determination of the Membrane Environment of CD59 in Living Cells. Biomolecules, 8(2), Article 28. https://doi.org/10.3390/biom8020028
- | Tunable DNA Hybridization Enables Spatially and Temporally Controlled Surface-Anchoring of Biomolecular Cargo at reposiTUm , opens an external URL in a new windowHager, R., Arnold, A., Sevcsik, E., Schütz, G. J., & Howorka, S. (2018). Tunable DNA Hybridization Enables Spatially and Temporally Controlled Surface-Anchoring of Biomolecular Cargo. Langmuir, 34(49), 15021–15027. https://doi.org/10.1021/acs.langmuir.8b01942
- | Protein Micropatterning Assay: Quantitative Analysis of Protein-Protein Interactions at reposiTUm , opens an external URL in a new windowSchütz, G. J., Weghuber, J., Lanzerstorfer, P., & Sevcsik, E. (2017). Protein Micropatterning Assay: Quantitative Analysis of Protein-Protein Interactions. Methods in Molecular Biology, 261–270. https://doi.org/10.1007/978-1-4939-6747-6_18
- | Proteins and lipids - a complicated relationship? at reposiTUm , opens an external URL in a new windowSevcsik, E., & Schütz, G. (2017). Proteins and lipids - a complicated relationship? ASBMB Today, 16(1), 9–10.
- | Monte Carlo simulations of protein micropatterning in biomembranes: effects of immobile sticky obstacles at reposiTUm , opens an external URL in a new windowArnold, A. M., Sevcsik, E., & Schütz, G. J. (2016). Monte Carlo simulations of protein micropatterning in biomembranes: effects of immobile sticky obstacles. Journal of Physics D: Applied Physics, 49(36), 364002. https://doi.org/10.1088/0022-3727/49/36/364002
- | Oxidized Phospholipids Inhibit the Formation of Cholesterol-Dependent Plasma Membrane Nanoplatforms at reposiTUm , opens an external URL in a new windowBrameshuber, M., Sevcsik, E., Rossboth, B. K., Manner, C., Deigner, H.-P., Peksel, B., Péter, M., Török, Z., Hermetter, A., & Schütz, G. J. (2016). Oxidized Phospholipids Inhibit the Formation of Cholesterol-Dependent Plasma Membrane Nanoplatforms. Biophysical Journal, 110(1), 205–213. https://doi.org/10.1016/j.bpj.2015.11.018
- | With or without rafts? Alternative views on cell membranes at reposiTUm , opens an external URL in a new windowSevcsik, E., & Schütz, G. J. (2016). With or without rafts? Alternative views on cell membranes. BioEssays, 38(2), 129–139. https://doi.org/10.1002/bies.201500150
- | GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane at reposiTUm , opens an external URL in a new windowSevcsik, E., Brameshuber, M., Fölser, M., Weghuber, J., & Honigmann, A. (2015). GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane. Nature Communications, 6, 69691–696910.
Books & Book Contributions
- | A DNA Origami-Based Biointerface to Interrogate the Spatial Requirements for Sensitized T-Cell Antigen Recognition at reposiTUm , opens an external URL in a new windowHellmeier, J., Platzer, R., Huppa, J. B., & Sevcsik, E. (2023). A DNA Origami-Based Biointerface to Interrogate the Spatial Requirements for Sensitized T-Cell Antigen Recognition. In C. Baldari & M. L. Dustin (Eds.), The Immune Synapse. Methods and Protocols (Vol. 2654, pp. 277–302). Humana. https://doi.org/10.1007/978-1-0716-3135-5_18
Inproceedings
- | Spatial requirements for T-cell receptor triggering probed via a DNA origami-based biointerface at reposiTUm , opens an external URL in a new windowHellmeier, J., Platzer, R., Huppa, J., & Sevcsik, E. (2024). Spatial requirements for T-cell receptor triggering probed via a DNA origami-based biointerface. In 3rd MOSBRI Scientific Conference: 10th - 13th June 2024, Ljubljana, Slovenia: Programme Abstracts (pp. 77–77).
- | Tailor-made biointerfaces on oxidic substrates via polymer brushes at reposiTUm , opens an external URL in a new windowHelfert, S., Hellmeier, J., Sevcsik, E., Liska, R., & Baudis, S. (2019). Tailor-made biointerfaces on oxidic substrates via polymer brushes. In Termis EU 2019 (p. 1338).
- | High resolution 3D printing of biomimetic microenvironments to study T-cell activation at reposiTUm , opens an external URL in a new windowDobos, A., Gruber, P., Steiger, W., Fülöp, G., Sevcsik, E., Schütz, G., & Ovsianikov, A. (2018). High resolution 3D printing of biomimetic microenvironments to study T-cell activation. In G. Fülöp (Ed.), Abstract Book.
- | Tailor-made Polymer Interfaces - Surfaces on Demand at reposiTUm , opens an external URL in a new windowHelfert, S., Hellmeier, J., Sevcsik, E., Liska, R., & Baudis, S. (2018). Tailor-made Polymer Interfaces - Surfaces on Demand. In VSS 2018 (pp. 84–85). Book-of-Abstracts.com.
- | Synthesis and Characterization of Polymer Linker Systems for Cell Studies at reposiTUm , opens an external URL in a new windowHelfert, S., Dworak, C., Sevcsik, E., Peterlik, H., Ret, D., Sauer, M., & Liska, R. (2017). Synthesis and Characterization of Polymer Linker Systems for Cell Studies. In Bypos Workshop Book 2017 (p. 29).
- | Design and Synthesis of Tailor-made Nanostructured Polymer Biointerfaces at reposiTUm , opens an external URL in a new windowHelfert, S., Dworak, C., Sevcsik, E., Peterlik, H., Sauer, M., Ret, D., & Liska, R. (2017). Design and Synthesis of Tailor-made Nanostructured Polymer Biointerfaces. In Danube Vltava Sava Polymer Meeting 2017 (p. OP-11). Book of Abstracts.com.
- | Synthesis and Characterization of Polymer Linker systems for T-cell activation at reposiTUm , opens an external URL in a new windowHelfert, S., Dworak, C., Sevcsik, E., Peterlik, H., Sauer, M., Ret, D., & Liska, R. (2017). Synthesis and Characterization of Polymer Linker systems for T-cell activation. In Advanced Polymers via Macromolecular Engineering (p. 133).
Preprints
- | Chemical characterization of extracellular vesicles at the sub-vesicle level at reposiTUm , opens an external URL in a new windowHondl, N., Neubauer, L., Ramos Garcia, V., Kuligowski, J., Bishara, M., Sevcsik, E., Lendl, B., & Ramer, G. (2025). Chemical characterization of extracellular vesicles at the sub-vesicle level. ChemRxiv. https://doi.org/10.34726/8660
Talks
- | Signaling from single TCRs? Dissecting binding kinetics and clustering in TCR-antigen recognition at reposiTUm , opens an external URL in a new windowSevcsik, E. (2024, June 2). Signaling from single TCRs? Dissecting binding kinetics and clustering in TCR-antigen recognition. Lymphocyte Antigen Receptor Signalling Workshop (2024), Siena, Italy.
- | Spatial requirements for T-cell receptor triggering probed via a DNA origami-based biointerface at reposiTUm , opens an external URL in a new windowSevcsik, E. (2024, May 15). Spatial requirements for T-cell receptor triggering probed via a DNA origami-based biointerface. 20th International Life Science Meeting, Krems an der Donau, Austria.
- | Designing functionalized DNA origami-based biointerfaces for probing T-cell activation at reposiTUm , opens an external URL in a new windowMajkova, A., Hellmeier, J., Platzer, R., Kopittke, C., Huppa, J., Schütz, G., & Sevcsik, E. (2023, December 1). Designing functionalized DNA origami-based biointerfaces for probing T-cell activation. Vienna Soft Matter Day, Wien, Austria.
- | Spatial requirements for T-cell receptor triggering probed via a DNA origami-based biointerface at reposiTUm , opens an external URL in a new windowSevcsik, E. (2023, September 19). Spatial requirements for T-cell receptor triggering probed via a DNA origami-based biointerface. 2023 Fall Meeting of the European Materials Research Society (E-MRS), Warschau, Poland.
- | Designing functionalized DNA origami-based biointerfaces for probing cell-cell interaction at reposiTUm , opens an external URL in a new windowMajkova, A., Hellmeier, J., Huppa, J. B., & Sevcsik, E. (2023, September 6). Designing functionalized DNA origami-based biointerfaces for probing cell-cell interaction. Active mechanics, from single cells to cell layers, tissues and development (SPLW02), Cambridge, United Kingdom of Great Britain and Northern Ireland (the).
- | Designing functionalized DNA origami-based biointerfaces for probing T-cell activation at reposiTUm , opens an external URL in a new windowMajkova, A., Hellmeier, J., Platzer, R., Huppa, J., & Sevcsik, E. (2023, August 29). Designing functionalized DNA origami-based biointerfaces for probing T-cell activation. 12th Single Molecule Localization Microscopy Symposium (SMLMS) 2023, Wien, Austria.
- | Protein micropatterning as a tool to probe the membrane environment of transmembrane proteins in live-cells at reposiTUm , opens an external URL in a new windowBishara, M., Brumovska, V., Arnold, A. M., Kalouskova, B., Fülöp, G., Schütz, G., & Sevcsik, E. (2023, August 28). Protein micropatterning as a tool to probe the membrane environment of transmembrane proteins in live-cells. 12th Single Molecule Localization Microscopy Symposium (SMLMS) 2023, Wien, Austria.
- | Comprehensive Fluorophore Blinking Platform for Detecting Nanoscale Protein Distributions at reposiTUm , opens an external URL in a new windowBrameshuber, E., Platzer, R., Rossboth, B., Sevcsik, E., Schneider, M., Schütz, G., & Huppa, J. B. (2023, August 28). Comprehensive Fluorophore Blinking Platform for Detecting Nanoscale Protein Distributions. 12th Single Molecule Localization Microscopy Symposium (SMLMS) 2023, Wien, Austria.
- | Determining the nanoscopic membrane environment of transmembrane proteins in live-cells with protein micropatterning at reposiTUm , opens an external URL in a new windowBishara, M., Brumovska, V., Arnold, A. M., Kalouskova, B., Fülöp, G., Schütz, G., & Sevcsik, E. (2023, August 2). Determining the nanoscopic membrane environment of transmembrane proteins in live-cells with protein micropatterning. European Biophysical Societies Association (EBSA Congress) 2023, Stockholm, Sweden.
- | A DNA origami-based biointerface for interrogating the spatial requirements of T-cell antigen recognition at reposiTUm , opens an external URL in a new windowSevcsik, E. (2023, July 11). A DNA origami-based biointerface for interrogating the spatial requirements of T-cell antigen recognition. CellNanOS und SFB - Seminar, Osnabrück, Germany.
- | Probing the spatial requirements for T-cell receptor triggering (invited talk) at reposiTUm , opens an external URL in a new windowSevcsik, E. (2023, April 13). Probing the spatial requirements for T-cell receptor triggering (invited talk). EMBO Workshop “ImmunoBiophysics: From fundamental physics to understanding the immune response,” Les Houches, France.
- | Probing plasma membrane organization and function using microstructured biointerfaces at reposiTUm , opens an external URL in a new windowSevcsik, E. (2023, January 10). Probing plasma membrane organization and function using microstructured biointerfaces. seminar series “Selected Topics in Membrane Biophysics,” Graz, Austria.
- | Distinct spatial requirements for TCR but not pMHC organization direct T-cell activation (talk) at reposiTUm , opens an external URL in a new windowSevcsik, E. (2022, September 22). Distinct spatial requirements for TCR but not pMHC organization direct T-cell activation (talk). ÖGMBT Jahrestagung, Wien, Austria.
- | Unraveling protein-lipid interactions in live-cells with protein micropatterning at reposiTUm , opens an external URL in a new windowBishara, M., Brumovska, V., Arnold, A. M., Fülöp, G., Schütz, G., & Sevcsik, E. (2022, September 11). Unraveling protein-lipid interactions in live-cells with protein micropatterning. Methods and Applications in Fluorescence, Göteborg, Sweden.
- | A DNA origami-based biointerface for probing the spatial requirements of cell surface receptor triggering (Invited talk) at reposiTUm , opens an external URL in a new windowSevcsik, E. (2022, September 7). A DNA origami-based biointerface for probing the spatial requirements of cell surface receptor triggering (Invited talk). 16th Multinational Congress on Microscopy, Brno, Czechia.
- | Micro- and nanostructured biointerfaces for studying cell surface receptor triggering at reposiTUm , opens an external URL in a new windowSevcsik, E. (2022, July 25). Micro- and nanostructured biointerfaces for studying cell surface receptor triggering. Membrane Symposium, Tulln/NÖ, Austria.
- | Spatial requirements for T-cell receptor triggering probed via a DNA origami-based biointerface at reposiTUm , opens an external URL in a new windowSevcsik, E. (2022, July 10). Spatial requirements for T-cell receptor triggering probed via a DNA origami-based biointerface. Meeting of the Austrian Biophysical Society, Strobl/Sbg, Austria.
- | A DNA origami-based biointerface for probing T-cell receptor triggering; invited talk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2022). A DNA origami-based biointerface for probing T-cell receptor triggering; invited talk. Gordon Research Conference on Biointerface Science, Barga-Gallicano, Italy.
- | A DNA origami-based biointerface for probing the spatial requirements of cell surface receptor triggering, invited talk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2022). A DNA origami-based biointerface for probing the spatial requirements of cell surface receptor triggering, invited talk. International Workshop “Frontiers in Physiology and Disease,” Ceske Budejovice/Czech Republic, online, Czechia.
- | DNA origami as a tool to study T-cell activation; invited speaker at reposiTUm , opens an external URL in a new windowSevcsik, E. (2022). DNA origami as a tool to study T-cell activation; invited speaker. Immuno-biophysics virtual lecture series, CNRS, Marseille, online, France.
- | DNA origami as a tool to study T-cell activation; invited talk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2022). DNA origami as a tool to study T-cell activation; invited talk. seminar series “Selected Topics in Membrane Biophysics,” UniversitätGraz, online, Austria.
- | Probing the membrane environment of plasma membrane proteins; invited talk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2022). Probing the membrane environment of plasma membrane proteins; invited talk. DGfB - Membrane Biophysics Meeting, Drübeck, Germany.
- | Wie die Nanobiophysik helfen kann, unser Immunsystem und vieles mehr zu verstehen; invited speaker at reposiTUm , opens an external URL in a new windowSevcsik, E. (2022). Wie die Nanobiophysik helfen kann, unser Immunsystem und vieles mehr zu verstehen; invited speaker. “Science” forum of VHS Wien, Wien, online, Austria.
- | A DNA origami-based biointerface for probing the spatial requirements of cell surface receptor triggering at reposiTUm , opens an external URL in a new windowSevcsik, E. (2021). A DNA origami-based biointerface for probing the spatial requirements of cell surface receptor triggering. Austrian Cluster for Tissue Regeneration Meeting, Wien, Austria.
- | DNA origami demonstrate the unique stimulatory power of single pMHCs as T-cell antigens at reposiTUm , opens an external URL in a new windowSevcsik, E. (2021). DNA origami demonstrate the unique stimulatory power of single pMHCs as T-cell antigens. Biophysical Society 65th Annual Meeting, United States of America (the).
- | Micro‐ and nanostructured biointerfaces for cell interaction at reposiTUm , opens an external URL in a new windowSevcsik, E. (2021). Micro‐ and nanostructured biointerfaces for cell interaction. Habilitandenseminar der Fakultät Physik, TU-Vienna, Austria.
- | Probing the membrane environment of plasma membrane proteins; invited talk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2021). Probing the membrane environment of plasma membrane proteins; invited talk. ITN PROTON Meeting, Prague, online, Czechia.
- | Probing the membrane environment of plasma membrane proteins at reposiTUm , opens an external URL in a new windowSevcsik, E. (2021). Probing the membrane environment of plasma membrane proteins. 13th European Biophysics Congress (EBSA), Wien, Austria.
- | Spatial requirements for T-cell receptor triggering probed via a DNA origami-based biointerface; invited talk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2021). Spatial requirements for T-cell receptor triggering probed via a DNA origami-based biointerface; invited talk. Purdue University, United States of America (the).
- | Spatial requirements for T-cell receptor triggering probed via a DNA origami-based biointerface; invited talk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2021). Spatial requirements for T-cell receptor triggering probed via a DNA origami-based biointerface; invited talk. seminartalk, University of Cambridge, Cambridge/UK, online, United Kingdom of Great Britain and Northern Ireland (the).
- | DNA origami demonstrate the unique stimulatory power of single pMHCs as T-cell antigens at reposiTUm , opens an external URL in a new windowSevcsik, E. (2020). DNA origami demonstrate the unique stimulatory power of single pMHCs as T-cell antigens. Cell Bio Virtual 2020, online, United States of America (the).
- | DNA Origami as a nanoscale platform for T cell activation at reposiTUm , opens an external URL in a new windowSevcsik, E. (2019). DNA Origami as a nanoscale platform for T cell activation. XXIth Annual Linz Winter Workshop, Linz/ÖO, Austria.
- | DNA origami as a nanoscale tool to study T cell activation, invited talk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2019). DNA origami as a nanoscale tool to study T cell activation, invited talk. SFB1032-Workshop, Benediktbeuern, Germany.
- | Nanoscale organization and mobility of ligands direct T cell activation at reposiTUm , opens an external URL in a new windowSevcsik, E. (2019). Nanoscale organization and mobility of ligands direct T cell activation. Biophysical Society 63rd Annual Meeting, Baltimore, United States of America (the).
- | Nanoscale organization of ligands directs T cell activation; contributed talk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2019). Nanoscale organization of ligands directs T cell activation; contributed talk. BioNanoMed 2019, Graz/Stmk, Austria.
- | DNA Origami as a nanoscale platform for T cell activation at reposiTUm , opens an external URL in a new windowSevcsik, E. (2018). DNA Origami as a nanoscale platform for T cell activation. 8th Regional Biophysics Conference (RBC), Zrece, Slovenia.
- | DNA origami as a nanoscale platform for T cell activation at reposiTUm , opens an external URL in a new windowSevcsik, E. (2018). DNA origami as a nanoscale platform for T cell activation. Biophysical Society 62nd Annual Meeting, San Francisco, United States of America (the).
- | Probing lipid interactions of plasma membrane proteins: a micropatterning approach at reposiTUm , opens an external URL in a new windowSevcsik, E. (2018). Probing lipid interactions of plasma membrane proteins: a micropatterning approach. 7th Wroclaw-Prague Seminar on Biophysics of Lipids, Wroclaw, Poland.
- | Probing lipid interactions of the T-cell receptor complex: a micropatterning approach at reposiTUm , opens an external URL in a new windowSevcsik, E. (2018). Probing lipid interactions of the T-cell receptor complex: a micropatterning approach. 20th Annual Linz Winter Workshop, Linz/OÖ, Austria.
- | Using micro- and nanostructured biointerfaces to study plasma membrane organization and function, invited seminartalk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2018). Using micro- and nanostructured biointerfaces to study plasma membrane organization and function, invited seminartalk. Invited seminar talk, DK NanoCell Colloquium, TU Wien, Austria.
- | Synthesis and Characterization of Polymer Linker Systems for T-cell Investigations at reposiTUm , opens an external URL in a new windowHelfert, S., Dworak, C., Sevcsik, E., Peterlik, H., Sauer, M., Ret, D., & Liska, R. (2017). Synthesis and Characterization of Polymer Linker Systems for T-cell Investigations. Workshop Additive manufacturing as a tool to create life in 3D, Brno, Czechia.
- | Probing the membrane environment of palmitoylated transmembrane proteins: a micropatterning approach at reposiTUm , opens an external URL in a new windowSevcsik, E. (2017). Probing the membrane environment of palmitoylated transmembrane proteins: a micropatterning approach. 9th ÖGMBT Annual Meeting 2017, Innsbruck, Austria.
- | Probing the membrane environment of palmitoylated transmembrane proteins: a micropatterning approach at reposiTUm , opens an external URL in a new windowSevcsik, E. (2017). Probing the membrane environment of palmitoylated transmembrane proteins: a micropatterning approach. TethMem 2017, Wien, Austria.
- | Biophysik - die Brücke zwischen Biologie und Physik; invited talk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2016). Biophysik - die Brücke zwischen Biologie und Physik; invited talk. 66th annual meeting of the Austrian Physical Society (ÖPG), Wien, Austria.
- | Combining protein micropatterning and single molecule microscopy to decipher plasma membrane organization at reposiTUm , opens an external URL in a new windowSevcsik, E. (2016). Combining protein micropatterning and single molecule microscopy to decipher plasma membrane organization. 8th ÖGMBT annual meeting, Graz/Stmk, Austria.
- | Combining protein micropatterning and single molecule microscopy to decipher plasma membrane organization at reposiTUm , opens an external URL in a new windowSevcsik, E. (2016). Combining protein micropatterning and single molecule microscopy to decipher plasma membrane organization. Regional Biophysics Conference (RBC) 2016, Triest, Italy.
- | GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane at reposiTUm , opens an external URL in a new windowSevcsik, E. (2016). GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane. Linz Winter Workshop, Linz/OÖ, Austria.
- | DNA origami platform for protein interaction analysis at reposiTUm , opens an external URL in a new windowMotsch, V., Hager, R., Sevcsik, E., Schäffler, F., Howorka, S., & Schütz, G. (2015). DNA origami platform for protein interaction analysis. 65th Annual Meeting of the Austrian Physical Society, Wien, Austria.
- | DNA origami platform for protein interaction analysis at reposiTUm , opens an external URL in a new windowMotsch, V., Hager, R., Sevcsik, E., Schäffler, F., Howorka, S., & Schütz, G. (2015). DNA origami platform for protein interaction analysis. Biophysical Society 59th Annual Meeting, Baltimore/USA, Non-EU.
- | DNA origami platform for protein interaction analysis at reposiTUm , opens an external URL in a new windowMotsch, V., Hager, R., Sevcsik, E., Schäffler, F., Howorka, S., & Schütz, G. (2015). DNA origami platform for protein interaction analysis. XVI. Annual Linz Winter Workshop 2015, Linz/OÖ, Austria.
- | Determination of the reach of a membrane proteins: is there a space for rafts?; seminartalk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2015). Determination of the reach of a membrane proteins: is there a space for rafts?; seminartalk. Seminartalk, Universität Graz, Inst. f. Molekulare Biowissenschaften, Graz, Austria.
- | GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane at reposiTUm , opens an external URL in a new windowSevcsik, E. (2015). GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane. 10th European Biophysics Congress, Dresden/Germany, EU.
- | GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane at reposiTUm , opens an external URL in a new windowSevcsik, E. (2015). GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane. 65th Annual Meeting of the Austrian Physical Society, Wien, Austria.
- | GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane at reposiTUm , opens an external URL in a new windowSevcsik, E. (2015). GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane. Biophysical Society 59th Annual Meeting, Baltimore/USA, Non-EU.
- | GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane at reposiTUm , opens an external URL in a new windowSevcsik, E. (2015). GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane. XVI. Annual Linz Winter Workshop 2015, Linz/OÖ, Austria.
- | Lipid rafts - From model membranes to live cells - Introduction to Single-molecule fluorescence microscopy techniques; invited talk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2015). Lipid rafts - From model membranes to live cells - Introduction to Single-molecule fluorescence microscopy techniques; invited talk. ITN SNAL Summer School on Biomaterials, Cells and Lipid Bilayers, Roccalumera/Italy, EU.
- | Protein micropatterning as a tool to decipher plasma membrane organization and protein interactions; invited talk at reposiTUm , opens an external URL in a new windowSevcsik, E. (2015). Protein micropatterning as a tool to decipher plasma membrane organization and protein interactions; invited talk. Workshop on Biomaterials and Their Interactions with Biological and Model Membranes, Salou/Spain, EU.
- | Creating obstacle courses for raft proteins - How micropatterning can help decipher plasma membrane organization at reposiTUm , opens an external URL in a new windowSevcsik, E. (2014). Creating obstacle courses for raft proteins - How micropatterning can help decipher plasma membrane organization. Linz Winter Workshop, Linz/OÖ, Austria.
- | Creating obstacle courses for raft proteins - How micropatterning can help decipher plasma membrane organization at reposiTUm , opens an external URL in a new windowSevcsik, E. (2014). Creating obstacle courses for raft proteins - How micropatterning can help decipher plasma membrane organization. Seminar Institut für Allgemeine Physik (IAP), TU Wien, Austria.
- | Determination of the reach of membrane proteins:is there a space for rafts? at reposiTUm , opens an external URL in a new windowSevcsik, E. (2014). Determination of the reach of membrane proteins:is there a space for rafts? 6th ÖGMBT (Österreichische Gesellschaft für Molekulare Biowissenschaften und Biotechnologie) Annual Meeting, Universitätszentrum Althanstrasse, Austria.
- | Determination of the reach of membrane proteins:is there a space for rafts? at reposiTUm , opens an external URL in a new windowSevcsik, E. (2014). Determination of the reach of membrane proteins:is there a space for rafts? Biomembrane Days, Berlin/Germany, EU.
- | Determination of the reach of membrane proteins:is there a space for rafts? at reposiTUm , opens an external URL in a new windowSevcsik, E. (2014). Determination of the reach of membrane proteins:is there a space for rafts? Linzer Forum Medizintechnik Medical Imaging, Linz/OÖ, Austria.
- | Protein micropatterning as a tool to decipher plasma membrane organization at reposiTUm , opens an external URL in a new windowSevcsik, E. (2013). Protein micropatterning as a tool to decipher plasma membrane organization. Invited seminar talk, MPI für Biophysikalische Chemie, Göttingnen/D, EU.
- | Protein micropatterning in live cells: a tool for creating membrane domains with raft-like properties at reposiTUm , opens an external URL in a new windowSevcsik, E. (2013). Protein micropatterning in live cells: a tool for creating membrane domains with raft-like properties. Biophysical Society 57th Annual Meeting, Philadelphia, Pennsylvania/USA, Non-EU.
- | Allostery in a disordered protein: Oxidative modifications to α-Synuclein act distally to regulate membrane binding at reposiTUm , opens an external URL in a new windowSevcsik, E. (2012). Allostery in a disordered protein: Oxidative modifications to α-Synuclein act distally to regulate membrane binding. XIV Linz Winter Workshop 2012, Linz/ÖO, Austria.
- | Using protein micropatterning to probe lipid-mediated protein interactions in the plasma membrane of live cells at reposiTUm , opens an external URL in a new windowSevcsik, E. (2012). Using protein micropatterning to probe lipid-mediated protein interactions in the plasma membrane of live cells. Arbeitsgruppentreffen der ÖGMBT Arbeitsgruppe “Single Molecule Biology,” Litschau/NÖ, Austria.
- | Using protein micropatterning to probe lipid-mediated protein interactions in the plasma membrane of live cells at reposiTUm , opens an external URL in a new windowSevcsik, E. (2012). Using protein micropatterning to probe lipid-mediated protein interactions in the plasma membrane of live cells. Euromembrane Conference: Membrane Dynamics in Physiology and Disease, Basel/Switzerland, Non-EU.
- | Using protein micropatterning to probe lipid-mediated protein interactions in the plasma membrane of live cells at reposiTUm , opens an external URL in a new windowSevcsik, E. (2012). Using protein micropatterning to probe lipid-mediated protein interactions in the plasma membrane of live cells. LipidomicNet Workshop, TU Wien, Austria.
Articles in refereed journals
- R. Platzer, J. Hellmeier, J. Göhring, I. Doel Perez, P. Schatzlmaier, C. Bodner, M. Focke-Tejkl, G.J. Schütz, E. Sevcsik, H. Stockinger, M. Brameshuber, J.B. Huppa (2023). Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion. EMBO Reports e57842
- J. Hellmeier, R. Platzer, J.B. Huppa, E. Sevcsik* (2023). A DNA origami-based biointerface to interrogate the spatial requirements for sensitized T-cell antigen recognition. Methods Mol. Biol. 2654, 277
- I. Hartl, V. Brumovska, Y. Strieder, A. Yasari, G.J. Schütz, E. Sevcsik*, I. Tiemann-Böge* (2023) Measurement of FGFR3 signaling at the cell membrane via total internal reflection fluorescence microscopy to compare the activation of FGFR3 mutants. J. Biol. Chem. 299, 102832
- J. Hellmeier, R. Platzer, V. Mühlgrabner, M.C. Schneider, E. Kurz, G.J. Schütz, J.B. Huppa, E. Sevcsik* (2021). Strategies for the site-specific decoration of DNA origami nanostructures with functionally intact proteins. ACS Nano 15, 15057
- A. Schromm, L. Paulowski, Y. Kaconis, F. Kopp, M. Koistinen, A. Donoghue, S. Keese, C. Nehls, J. Wernecke, P. Garidel, E. Sevcsik, K. Lohner, S. Sanchez-Gomez, G. Martinez-de-Tejada, K. Brandenburg, M. Brameshuber, G.J. Schütz, J. Andrä, T. Gutsmann (2021). Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes. PNAS 118, e2101721118
- J. Hellmeier, R. Platzer, A.S. Eklund, T. Schlichthärle, A. Karner, M.C. Schneider, V. Motsch, E. Kurz, V. Bamieh, M. Brameshuber, J. Preiner, R. Jungmann, H. Stockinger, G.J. Schütz, J.B. Huppa, E. Sevcsik* (2021). DNA origami demonstrate the unique stimulatory power of single pMHCs as T-cell antigens. PNAS 118, e2016857118
- R. Platzer, B.K. Rossboth, M.C. Schneider, E. Sevcsik, F. Baumgart, H. Stockinger, G.J. Schütz, J.B. Huppa, M. Brameshuber (2020). Unscrambling fluorophore blinking for comprehensive cluster detection via photoactivated localization microscopy. Nature Commun. 11, 4993
- A. M. Arnold, A.W.A.F. Reismann, E. Sevcsik, G.J. Schütz (2020). Monte Carlo simulations of protein micropatterning in biomembranes: effects of immobile nanofeatures with reduced diffusivity. J. Phys. D: Appl. Phys. 53, 435401
- T. Váradi, M. Schneider, E. Sevcsik, D. Kiesenhofer, F. Baumgart, G. Batta, T. Kovács, R. Platzer, J.B. Huppa, J. Szöllősi, G.J. Schütz, M. Brameshuber, P. Nagy (2019). Homo- and heteroassociations drive activation of ErbB3. Biophys. J. 117, 1935
- V. Motsch, M. Brameshuber, F. Baumgart, G.J. Schütz, E. Sevcsik* (2019). A micropatterning platform for quantifying interaction kinetics between the T cell receptor and an intracellular binding protein. Scientific Reports 9, 3288
- M. Lindner, A. Tresztenyak, G. Fülöp, W. Jahr, A. Prinz, I. Prinz, J. Danzl, G.J. Schütz, E. Sevcsik* (2019). A fast and simple contact printing approach to generate 2D protein nanopatterns. Frontiers in Chemistry 6, 655
- R. Hager, A.M. Arnold, E. Sevcsik, G.J. Schütz and S. Howorka (2018). Tunable DNA hybridization enables spatially and temporally controlled surface-anchoring of biomolecular cargo. Langmuir 34, 15021-15027
- G. Fülop, M. Brameshuber, A.M. Arnold, G.J. Schütz, E. Sevcsik* (2018). Determination of the membrane environment of CD59 in living cells. Biomolecules 8, 28
- M. Brameshuber, F. Kellner, B.K. Rossboth, H. Ta, K. Alge, E. Sevcsik, J. Göhring, M. Axmann, F. Baumgart, N.R.J. Gascoigne, S.J. Davis, H. Stockinger, G.J. Schütz and J.B. Huppa (2018). Monomeric TCRs drive T cell antigen recognition. Nature Immun. 19, 487-496
- G.J. Schütz, J. Weghuber, P. Lanzerstorfer, E. Sevcsik* (2017). Protein Micropatterning Assay: Quantitative Analysis of Protein–Protein Interactions. Methods Mol. Biol. 1550, 261-270
- A.M. Arnold, E. Sevcsik, G.J. Schütz (2016). Monte Carlo simulations of protein micropatterning in biomembranes: effects of immobile sticky obstacles. J. Phys. D: Appl. Phys. 49, 364002
- E. Sevcsik* and G.J. Schütz* (2016). With or without rafts? Alternative views on cell membranes. Bioessays 38, 129-139
- M. Brameshuber, E. Sevcsik, B. K. Rossboth, C. Manner, HP. Deigner, B. Peksel, M. Péter, Z. Török, A. Hermetter, G. J. Schütz (2016). Oxidized phospholipids inhibit the formation of cholesterol-dependent plasma membrane nanoplatforms. Biophys. J. 110, 205-213
- E. Sevcsik*, M. Brameshuber, M. Fölser, J. Weghuber, A. Honigmann, G.J. Schütz* (2015). GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane. Nature Commun. 6, 6969
- A.R. Braun, E. Sevcsik, P. Chin, E. Rhoades, S. Tristram-Nagle, J.N. Sachs (2012). α-Synuclein induces both positive mean curvature and negative Gaussian curvature in membranes. J. Am. Chem. Soc. 134, 2613
- E. Sevcsik, A. Trexler, J. Dunn, E. Rhoades (2011). Evidence for allostery in a disordered protein: oxidative modifications to α-synuclein act distally to regulate membrane binding. J. Am. Chem. Soc. 133, 7152
- S. Strobach, R. Kunert, J. Stadlmann, P. Messner, E. Sevcsik, G. Lhota, H. Katinger, K. Vorauer-Uhl (2009). Topological transformation of liposomes by a membrane-affecting domain of recombinant human erythropoietin, J. Liposome Res. 20, 24
- E. Sevcsik*, G. Pabst, W. Richter, S. Danner, H. Amenitsch, K. Lohner (2008). Interaction of LL-37 with model membrane systems of different complexity – Influence of the lipid matrix, Biophys. J 94, 4688
- E. Sevcsik, G. Pabst, A. Jilek, K. Lohner (2007). How lipids influence the mode of action of membrane-active peptides, Biochim. Biophys. Acta 1768, 2586
- H. Reisinger, E. Sevcsik, K. Vorauer-Uhl, K. Lohner, H. Katinger, R. Kunert (2007). Serum-free transfection of CHO-cells with tailor-made unilamellar vesicles, Cytotechnology 54, 157
- B. Pozo Navas, K. Lohner, G. Deutsch, E. Sevcsik, K.A. Riske, R. Dimova, P. Garidel, G. Pabst (2005). Composition dependence of vesicle morphology and mixing properties in a bacterial model membrane system, Biochim. Biophys. Acta 1716, 40
- O. Konovalov, S.M. O’Flaherty, E. Saint-Martin, G. Deutsch, E. Sevcsik, K. Lohner (2005). The bending rigidity of phospholipid monolayers in the presence of an antimicrobial frog peptide studied by X-ray grazing incidence diffraction, Physica B 357, 185
- A. Loidl, E. Sevcsik, G. Riesenhuber, H.P. Deigner, A. Hermetter (2003). Oxidized phospholipids in minimally modified low density lipoprotein induce apoptotic signaling via activation of acid sphingomyelinase in arterial smooth muscle cells, J. Biol. Chem. 278, 32921
Book contributions
- K. Lohner, E. Sevcsik, G. Pabst (2007). Liposome based membrane mimetic systems: Implications for lipid-peptide interactions, in Advances in Planar Lipid Bilayers Vol. 6, (Ed. A. Leitmannova Liu), Elsevier, New York, 103
Articles in non-refereed journals
E. Sevcsik and G.J. Schütz (2017). Proteins and lipids – a complicated relationship? ASBMB Today 16, 9-10
E. Sevcsik (2021). Origami mit DNA - Wie DNA-Nanotechnologie helfen kann, unser Immunsystem besser zu verstehen.TU Wien alumni club bulletin 51, 8-9