TU-Dx PhD position

2D Materials for sensitive Analytical Chemistry 

 

doctoral school details

2D layered nanomaterials have triggered high interest in the field of bioanalytical chemistry due to several advantageous properties. In particular the photothermal conversion properties of MoS2 makes it a very promising material for laser desorption/ionization (LDI) and matrix-assisted LDI (MALDI) mass spectrometry (MS) because MoS2 sheet edges are active sites to dissociate H2 and associate H+, supporting by this the formation of protonated and deprotonated molecular ions for bioanalysis. 

The applicability of this promising material for laser-based applications is so far rather unexplored. We will evaluate 2D nanomaterial synthesized by our project partners for their potential application for bioanalysis. 

Ex vivo oxidation assays for tissues and biological fluids will be developed to study UV induced oxidations to further the development of non animal experiments. And bifunctionalized MoS2 will innovatively be combined with MS imaging for cutting-edge multimodal imaging approaches.

Your Profile:

  • Interest in chemistry, analytical chemistry and/or 2D materials.
  • Interest in mass spectrometry and basic ionization processes
  • Master's degree in chemistry, biology, materials science, or similar field of study.

If you are interested, please contact martina.marchetti-deschmann (a) tuwien.ac.at 

Position open until filled

Aim of the project is Single Protein Mass Analysis with a sensitivity a million times more sensitive than conventional Mass Spec

Aim of the project is single-protein mass analysis a million times more sensitive than conventional mass spectrometry (R) S.Sch.

 

 

Single Molecule on a balance

Single Molecule Analysis

There is a big demand for the identification of proteins with ever-increasing sensitivity and in complex samples, in particular, for emergent single-cell protein profiling. However, most protein species in mammalian cells are only available in low concentrations, and the limited sensitivity of mass spectrometry only allows for the detection of the most abundant proteins with millions of copies per cell.

The consortium with collaborators at TU Wien, ETH Zurich and the Niels Bohr Institute of Copenhagen University has unique competence for sensor concepts, which will allow us to develop new approaches to measuring mass. We will develop single-protein UV-Vis & IR absorption spectroscopy and single-protein gravimetric mass spectrometry. 

In this project we bring a radically new analysis technology to the field of protein analysis. To create this novel technology, this project engages contributions from physics, electrical engineering, microsystem technology, machine learning, analytical chemistry, and biochemistry. It is the combination of these disciplines that is at the heart of the success of this project. 

Your profile:

  • curios, pro-active, eager to work in a highly motivatedwork environment
  • interested in basic research
  • skills in Chemistry, Electrical Engineering, Physics or similar research fields

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If you have further questions please contact

martina.marchetti-deschmann ( a ) tuwien.ac.at