Multielectrodes for biomedical systems

On a CMOs-based electrode array (shown enlarged on the lower left), grow human skin cells (HDF cells).

© Maximilian Ell | BME

In-vitro multielectrode-based biomedical systems constitute an attractive platform for cellular diagnostics and research. With a special emphasis on electrogenic cells (neurons) they allow for the investigation of bioelectronic circuits and assemblies at cellular level.

Our goal is to develop and apply novel electrode-based platform for neuroscience research and biotechnological application. Using high-channel count electrode arrays (i.e. CMOS-based MEAs) large datasets are recorded and analyzed using customized algorithms.

 

Figure: Fibroblasts on electrode array

Neuroelectronic devices and interfacing

State-of-the art neuroprosthetics will be improved if bidirectional interfacing allows for rapid  adjustment of the therapeutic intervention. Towards such goal we aim for electrical recording and simultaneous stimulation at single cell scale using high-density electrode arrays and appropriate read-out schemes.

Retina-on-Chip

Retina sample on High Density CMOS Multielectrode array

© Adapted 2022 Andreea Elena Cojocaru | Front. Cell. Neurosci.

The ex vivo retina constitutes an attractive tissue for many biomedical applications. It can easily be interfaces to various electrode configuration and be stimulated over extended times to investigate basic questions in neuroscience and various disease models.

 

Figure: Retina sample on High Density CMOS Multielectrode array