Veranstaltungen

16. Mai 2025, 14:00 bis 15:00

Michael Grunze, MPI für medizinische Forschung, Heidelberg/Deutschland

Seminar

Micro Arrays: a high throughput method for antibiotic screening

Micro-patterned super-hydrophobic/ hydrophilic surfaces are used for medical diagnostics and drug screening. I will discuss the fabrication of these arrays with focus on oil infused hydrophobic surface. The infusion of oils into these surfaces creates so called SLIPS (slippery) surfaces which effectively suppress bacterial adhesion. Their preparation has been followed in situ by synchrotron holo-tomography with 50 nm resolution, showing the formation of a complex polymer/air/oil/water interface. Tests in contact with bacteria demonstrate their excellent-but limited- non-fouling properties. Bacterial film formation starts on defects and then covers the whole surface by first building bridges between defects in the SLIPS surface.

These micro-patterned super-hydrophobic/ hydrophilic surfaces are used to separate and prevent mixing of aqueous droplets confined in the hydrophilic areas. These Droplet Micro Arrays (DMA) can contain cells, bacteria, zebrafish embryos, or dissolved chemical compounds (drugs) and are used as high throughput biomedical and biochemical screening and drug discovery platforms. In this talk I will focus on their use as antibiotic drug screens for bedside personalized medical applications.

Kalendereintrag

Veranstaltung Details

Veranstaltungsort
SEM.R. DB gelb 05 B
1040 Wien
Wiedner Hauptstraße 8-10/E134
Veranstalter
IAP
Manuela Marik
marik@iap.tuwien.ac.at
Öffentlich
Ja
Kostenpflichtig
Nein
Anmeldung erforderlich
Nein