Events
16. May 2025, 14:00 until 15:00
Michael Grunze, MPI für medizinische Forschung, Heidelberg/Deutschland
Seminar
Micro-patterned super-hydrophobic/ hydrophilic surfaces are used for medical diagnostics and drug screening. I will discuss the fabrication of these arrays with focus on oil infused hydrophobic surface. The infusion of oils into these surfaces creates so called SLIPS (slippery) surfaces which effectively suppress bacterial adhesion. Their preparation has been followed in situ by synchrotron holo-tomography with 50 nm resolution, showing the formation of a complex polymer/air/oil/water interface. Tests in contact with bacteria demonstrate their excellent-but limited- non-fouling properties. Bacterial film formation starts on defects and then covers the whole surface by first building bridges between defects in the SLIPS surface.
These micro-patterned super-hydrophobic/ hydrophilic surfaces are used to separate and prevent mixing of aqueous droplets confined in the hydrophilic areas. These Droplet Micro Arrays (DMA) can contain cells, bacteria, zebrafish embryos, or dissolved chemical compounds (drugs) and are used as high throughput biomedical and biochemical screening and drug discovery platforms. In this talk I will focus on their use as antibiotic drug screens for bedside personalized medical applications.
Event details
- Event location
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SEM.R. DB gelb 05 B
1040 Wien
Wiedner Hauptstraße 8-10/E134 - Organiser
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IAP
Manuela Marik
marik@iap.tuwien.ac.at - Public
- Yes
- Entrance fee
- No
- Registration required
- No