This year’s Biophysical Society Annual Meeting, opens an external URL in a new window took place from 19-23th February in San Francisco, California. From our group, Magdalena Schneider, Lukas Velas and Christoph Trenzinger participated in the meeting and presented their newest research. Magdalena presented a flash talk and a poster “Don’t be fooled by randomness: Valid p-values for single molecule microscopy”, Lukas presented a poster “3D Super-resolution microscopy on the immunological synapse at isotropic precision below 15 nm” and Christoph presented a poster “A microdevice for studying the mechanobiology of T-cells on antigen presenting surfaces”. It was great to finally meet researchers from all over the world in person again, to talk about science and exchange new ideas.