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Valid p-values for single molecule microscopy

scientific illustration shows Probability density function of the summary statistics

© TU Wien

Probability density function of the summary statistics.

The p-value is calculated based on the value observed for a sample.

The article “Don’t Be Fooled by Randomness: Valid p-Values for Single Molecule Microscopy” was released in Frontiers in Bioinformatics, opens an external URL in a new window. Here, Magdalena and Gerhard describe ways for obtaining valid p-values in two selected applications of single molecule microscopy: nanoclustering in single molecule localization microscopy and single molecule trajectories. Particularly, the article shows how the problems of multiple testing and correlated data can be circumvented, thus ensuring valid and reliable results of significance tests.